THE JOYFUL REDUCTION OF UNCERTAINTY

Tag Archives: psychiatry

SSC Journal Club: Cipriani On Antidepressants

I. The big news in psychiatry this month is Cipriani et al’s Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. It purports to be … Continue reading

Powerless Placebos

[All things that have been discussed here before, but some people wanted it all in a convenient place] The most important study on the placebo effect is Hróbjartsson and Gøtzsche’s Is The Placebo Powerless?, updated three years later by a … Continue reading

Book Review: Madness And Civilization

[Content warning: Severe mistreatment of the mentally ill. Through this post, I’ll be following Foucault in using the politically incorrect term “madness” rather than the more modern “mental illness”, because a big part of his point is worrying about the … Continue reading

Adderall Risks: Much More Than You Wanted To Know

[Previously in series: Antidepressant Pharmacogenomics: Much More Than You Wanted To Know; SSRIs: Much More Than You Wanted To Know, etc. This is all preliminary and you should not take it as a reason to change successful medical care. None … Continue reading

What To Make Of New Positive NSI-189 Results?

I. I wanted NSI-189 to be real so badly. Pharma companies used to love antidepressants. Millions of people are depressed. Millions of people who aren’t depressed think they are. Sell them all a pill per day for their entire lifetime, … Continue reading

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Against Rat Park

I. Rat Park is a famous study in which lab rats were kept in a really nice habitat that satisfied their every need. Contrary to the usual results with lab animals, scientists couldn’t get these happier rats addicted to drugs. … Continue reading

SSC Journal Club: Serotonin Receptors

Pop science likes to dub dopamine “the reward chemical” and serotonin “the happiness chemical”. God only knows what norepinephrine is, but I’m sure it’s cutesy. In real life, all of this is much more complicated. Dopamine might be “the surprisal … Continue reading

Toward A Predictive Theory Of Depression

[Epistemic status: Total wild speculation] I. The predictive processing model offers compelling accounts of autism and schizophrenia. But Surfing Uncertainty and related sources I’ve read are pretty quiet about depression. Is there a possible PP angle here? Chekroud (2015) has … Continue reading

My IRB Nightmare

[Epistemic status: Pieced together from memory years after the event. I may have mis-remembered some things or gotten them in the wrong order. Aside from that – and the obvious jokes – this is all true. I’m being deliberately vague … Continue reading

Why Is Clozapine So Great?

[Epistemic status: Very speculative; I don’t fully understand a lot of the studies involved] Clozapine is an antipsychotic drug sometimes used to treat schizophrenia. Like most antipsychotics, it works by blocking dopamine receptors in the brain. Conventional wisdom among psychiatrists … Continue reading

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